Sesame oil

• BPRefined Sesame Oil
• JPSesame Oil
• Ph. Eur.Sesame Oil, Refined
• USP–NFSesame Oil

benne oil; gingelly oil; oleum sesami; sesami oleum raffinatum; teel oil

Refined fixed oil obtained from the seeds of Sesamum indicum L. (a mixture of triglycerides, mainly of oleic and linoleic acids) · [8008-74-0]

Polymer, mixture or material of variable composition — no single molecular formula applies.

Oleaginous vehicle

Typical concentrations: — · Dosage forms: Sterile (parenteral/ophthalmic)

Used mainly as a vehicle for intramuscular depot injections of lipophilic drugs, such as steroid hormones and long-acting antipsychotic esters (for example haloperidol and fluphenazine decanoates), where it may form the whole of the vehicle. It is also used as a solvent in oral capsules, in topical and cosmetic products, in emulsions and in self-emulsifying and other lipid-based delivery systems, and widely as an edible oil.

A clear, pale yellow oil that is almost odourless and has a bland taste. It solidifies to a buttery mass at about −5 °C.

Density

≈ 0.92 g/cm³

Iodine value

≈ 103–116

Saponification value

≈ 188–195

Fatty acid composition

mainly oleic and linoleic acids (each roughly 35–55%), with smaller amounts of palmitic and stearic acids

Solubility

miscible with chloroform, ether, light petroleum and carbon disulfide; slightly soluble in ethanol; practically insoluble in water

More resistant to oxidative rancidity than most fixed oils because it contains natural antioxidants (lignans such as sesamol and sesamolin). It can be sterilised by dry heat. Store in a well-filled, airtight, light-resistant container, avoiding exposure to excessive heat.

Saponified by alkali hydroxides; may react with strong oxidising agents.

Obtained by expression or solvent extraction of the seeds of Sesamum indicum, followed by refining (degumming, neutralisation, bleaching and deodorisation). Grades for parenteral use meet tighter limits on acid value, water and peroxides.

An edible oil that is generally non-toxic and non-irritant. Sesame is, however, a recognised food allergen, and hypersensitivity reactions, including anaphylaxis, have been reported after oral use and after injection of products formulated in sesame oil. Oily intramuscular injections can cause local pain and reactions at the injection site.

Observe normal precautions for the quantity handled. Spills are slippery; the oil is combustible.

Widely used as an edible oil. Included in the FDA Inactive Ingredient Database (intramuscular and subcutaneous injections, oral capsules and topical preparations) and in parenteral and non-parenteral medicines licensed in Europe.

Almond oil; canola oil; castor oil; corn oil; cottonseed oil; peanut oil; soybean oil.

Its good oxidative stability and low tendency to crystallise on cooling make it a preferred vehicle for oily depot injections; benzyl alcohol or benzyl benzoate is often added as a cosolvent or preservative. Patients with sesame allergy should be identified before oily injections are given.